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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: Direct acting antiviral (DAA) treatments may reduce the elevated α fetoprotein (AFP), but data on how, the frequency of baseline AFP elevations and their related factors, AFP dynamics during and after DAAThis retrospective study included 141 patients with CHC without hepatocellular carcinoma who received DAADAA treatment resulted in AFP normalization as early as treatment week 2.

Keywords： chronic hepatitis C α fetoprotein direct acting antiviral treatment cirrhosis

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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract: Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAAA number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will

Keywords： direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors

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Characteristics of force acting on adjustable axial flow pump blade

WEI Peiru, CHEN Hongxun, LU Wei

Frontiers in Energy 2008, Volume 2, Issue 4, Pages 508-513 doi: 10.1007/s11708-008-0054-x

Abstract: three-dimensional turbulent flow of adjustable axial-flow pump arrangement was simulated, and the force acting

Keywords： three-dimensional adjustable axial-flow calculated FEM centrifugal

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Developing “precise-acting” strategies for improving anaerobic methanogenesis of organic waste: Insights

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 6, doi: 10.1007/s11783-021-1508-1

Abstract: system and cannot directly enhance methanogenesis in a targeted manner, which was defined as “broad-actingThese “precise-acting” strategies are expected to achieve an efficient methanogenesis process and enhance

Keywords： Methanogenesis Anaerobic digestion Enhancing strategy Electron transfer Organic waste

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization

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Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4, Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: Many scientific efforts have been made to penetrate the blood-brain barrier and target glioblastoma cells, but the outcomes have been limited. More attention should be given to local inhibition of recurrence after glioblastoma resection to meet real medical needs. A biodegradable wafer containing the chemotherapeutics carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU) was the only local drug delivery system approved for clinical glioblastoma treatment, but with a prolonged survival time of only two months and frequent side effects. In this study, to improve the sustained release and prolonged therapeutic effect of drugs for inhibiting tumor recurrence after tumor resection, both free BCNU and BCNU- poly (lactic-co-glycolic acid) (the ratio of lactic acid groups to glycolic acid groups is 75/25) nanoparticles were simultaneously loaded into natural extracellular matrix hydrogel from pigskin to prepare BCNU gels. The hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removal in a fully characterized resection rat model. Free drugs were released instantly to kill the residual tumor cells, while drugs in nanoparticles were continuously released to achieve a continuous and effective inhibition of the residual tumor cells for 30 days. These combined actions effectively restricted tumor growth in rats. Thus, this strategy of local drug implantation and delivery may provide a reliable method to inhibit the recurrence of glioblastoma after tumor resection in vivo.

Keywords： BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3, Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: Their potent antiviral properties indicated the prospect of new drugs.

Keywords： benzimidazole coxsackie virus B₃ antiviral properties

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG

Frontiers of Agricultural Science and Engineering Pages 110-119 doi: 10.15302/J-FASE-2021390

Abstract: NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field

Keywords： antiviral plant protectant antiviral in the greenhouse field evaluation L-trp-NCA synthesis optimization

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virus infections. The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to viral clearance from the central nervous system (CNS), whereas the ability to evade such expression and activation contributes to virulence and pathogenicity. In this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussed, including recruiting leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immune cells that are essential for viral clearance. In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive immune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus

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ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract: Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection hasThese antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeuticSpecific attention is given to the antiviral mechanisms of the molecules along with their integrative

Keywords： antimicrobial proteins / antiviral profiling of bacteriocins / antiviral therapeutics / immunomodulation

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Additive direct-write microfabrication for MEMS: A review

Kwok Siong TEH

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4, Pages 490-509 doi: 10.1007/s11465-017-0484-4

Abstract:

Direct-write additive manufacturing refers to a rich and growing repertoire of well-established fabricationAt the macroscale, direct-write techniques such as stereolithography, selective laser sintering, fusedThe technological premises of all direct-write additive manufacturing are identical—convertingWhile still at its infancy, direct-write additive manufacturing techniques at the microscale have theWith current direct-write additive manufacturing technologies, it is possible to fabricate unsophisticated

Keywords： direct-write additive manufacturing microfabrication MEMS

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Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12, Pages 1689-1699 doi: 10.1007/s11705-022-2186-7

Abstract: Radicals are important intermediates in direct coal liquefaction.

Keywords： direct coal liquefaction hydrogen-donor solvent induced pyrolysis radical mechanism density functional

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Design and analysis of a new high frequency double-servo direct drive rotary valve

Muzhi ZHU,Shengdun ZHAO,Jingxiang LI

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 4, Pages 344-350 doi: 10.1007/s11465-016-0406-x

Abstract:

Researchers have investigated direct drive valve for many years to solve problems, such as fluid forceThis paper studied the high frequency double-servo direct drive rotary valve (DDRV), and proposed a novel

Keywords： direct drive rotary valve computational fluid dynamics (CFD) flow regulation

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Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 158-165 doi: 10.1007/s11684-014-0340-4

Abstract: The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimesterIn order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancyand after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral

Keywords： antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission

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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4, Pages 318-326 doi: 10.15302/J-FASE-2015080

Abstract: Garlic ( Liliaceae) has been safely used for more than 5000 years, and research on garlic extract is rapidly increasing because of its multiple biological functions. The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursal disease virus (IBDV)-infected specific pathogen free male white leghorn chicken were examined through histopathological, immunohistochemical, and Western blot analyses, and enzyme-linked immunosorbent assay. The results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) on bursal lesions after IBDV infection. In particular, protein expression of IBDV in the bursa decreased in Group GM1, indicating that GM administration decreased IBDV replication in the bursa. Furthermore, immunoglobulin M- and A-bearing B lymphocytes significantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral administration of 5 mg·kg GM offers moderate protection against B cell destruction after IBDV infection. During infection, the concentration of bursal interferon gamma (IFN-g) increased and peaked in Group GM1 earlier than in Group T (IBDV-exposed), demonstrating that GM administration prompted the production of IFN-g to protect against IBDV infection.

Keywords： garlic infectious bursal disease virus (IBDV) antiviral effect IgM-bearing B lymphocyte